Showing posts with label This Day in Medical History. Show all posts
Showing posts with label This Day in Medical History. Show all posts

Thursday, December 24, 2020

This Day in Medical History (Benjamin Rush, Reforming Doctor Who Signed Declaration of Independence, Born)

Dec. 24, 1745—Benjamin Rush, a doctor at the forefront of intellectual and reform movements in the first four decades of the American republic—including signing the Declaration of Independence—was born in Byberry Township, Penn. (The date used here was according to the Julian Calendar that prevailed in England and its colonies at the time.)

Last week, I wrote a post about another underrated Founding Father: John Jay. But, in its way, Rush’s career was more varied, more interesting—and more tragic. After all, how many other figures are considered so crucial to the origins of abolitionism, prison reform, psychiatry, eugenics, and substance abuse treatment—or been forced to put many of his concepts into practice by treating his own mentally ill son?

As a member of the Continental Congress whose activities ranged across multiple fields, Rush may have been surpassed only by two friends who also signed the Declaration, Benjamin Franklin and Thomas Jefferson. He embodied the best notions of the American Enlightenment for his belief in republicanism, toleration, scientific progress, and the elevating impact of education.

Yet, though regarded as the most famous and brilliant American physician of his time, his renown faded somewhat in the two centuries after his death for three reasons: his relatively brief political career, a longtime lack of access to his copious writings, and out-of-context misunderstandings about some of the more controversial aspects of his medical career.

In recent years, Rush has become the focus of some long-overdue scholarly attention. First, Stephen Fried’s highly acclaimed biography of the doctor appeared two years ago. Second, the current COVID-19 pandemic has led scholars to re-examine Rush’s controversial role in a major epidemic of his career: a Yellow Fever outbreak in Philadelphia.

Though not the sole physician who signed the Declaration, Rush was the only one to receive a university education in medicine (the College of Philadelphia, then the University of Edinburgh).

From his late 20s on, he became active in politics: persuading the recent English immigrant Thomas Paine to call his incendiary pro-revolutionary pamphlet Common Sense; discussing how to advance the new movement while dining at Philadelphia’s City Tavern with John Adams, Thomas Jefferson and George Washington; and, after signing the Declaration, leaving his pregnant wife behind to serve as physician in chief of the military hospital of the Middle Department of the Continental Army.

In the latter frenetic period, Rush was a trusted confidante and admirer of Washington: witnessing him clutching a page saying “Victory or death” (the watchword for the attack) before crossing the Delaware at the Battle of Trenton; treating the dying Gen. Hugh Mercer at the Battle of Princeton; slipping out of the clutches of the British after being briefly captured at the Battle of Brandywine; and writing an essay on  improving soldiers’ medical care that Washington pressed on his subordinates.

But before long, Rush would also display the habit of caustic, impolitic and sometimes indiscreet writing that attracted a host of enemies. He became appalled by medical treatment of soldiers at the hands of his superior, John Shippen, then at the Continental Congress for clearing him of wrongdoing.

Rush made an even more significant enemy when he penned an anonymous letter to Patrick Henry that was critical of Washington. Henry disregarded Rush’s plea to burn the letter immediately, instead passing it along to the general. Washington was so angry at Rush’s duplicity that the doctor felt compelled to resign his post.

In the 1780s, students rather than soldiers became the primary focus of Rush’s attention. At the University of Pennsylvania, he served in a number of capacities over the years, including professor of chemistry, professor of the theory and practice of medicine, and professor of the institutes of medicine and clinical practice. Unlike many of the other Founding Fathers, Rush was egalitarian in outlook, believing that a good education should be enough to qualify candidates for public office.

All the while he was lecturing to enthralled students (more than 3,000 in his 45-year career), Rush was maintaining a vigorous publication schedule (an estimated 85 significant publications, including the first American chemistry textbook) and becoming what would now be thought of as a public intellectual on health and educational matters:

* He founded Dickinson College in Carlisle, Pennsylvania (1783), Franklin College (now Franklin and Marshall) at Lancaster (1787), and the College of Physicians (also 1787);

* He sought, at Pennsylvania Hospital, the nation's first hospital, to get better funding for the mentally ill, and to stop the shameful practice of warehousing them;

* He called for treating addiction as a medical problem years before this became standard practice;

* He sought to reconcile two modes of beliefs that he heartily embraced: rationalism and religion;

* He proposed a national system of public education with a federal university to train public servants; and

* He advocated for the education of women.

On top of all these efforts, Rush not only called for an end to slavery but, differing from the conventional wisdom of the time, declared that there was nothing physically different about African-Americans that would prevent them from achieving as much as whites.

Unfortunately, Rush endangered his reputation for being in the vanguard of progressive thought—not to mention his professional credibility—by his role in Philadelphia’s yellow fever epidemic of 1793. (A thorough but critical examination of his role is provided by Robert L. North's "Benjamin Rush, MD: Assassin or Beloved Healer?" in a 2000 article for the Baylor University Medical Center Proceedings.)

At the start of the epidemic, Rush’s standing with the public actually rose, as he was one of the few physicians even to stay in the city to treat patients. But no approach he tried with patients seemed to work.

At this point, recalling a 1744 medical paper, Rush hit on the expedient of bloodletting and purging. Even when that didn’t work, he only resorted to it all the more often. (Ironically, Rush had stumbled onto they key to yellow fever outbreaks—his notes refer at one point to “Moschetoes” that were “uncommonly numerous”—but he never made the connection to the disease’s origin.)

William Safire’s novel Scandalmonger (2000) takes the viewpoint of Rush’s enemies by depicting him as a "murderous quack" and "Dr. Death," but it leaves out an important bit of context: Nobody else at the time had the least idea of what caused the disease. But the damage to the esteemed doctor’s credibility was done. He felt compelled to withdraw from some of his positions, and even his practice suffered for a time.

Adams’ appointment of his old friend as Treasurer of the U.S. Mint enabled Rush to rebuild his reputation even as he re-entered public service. He remained wed, fatally, to his old idea on fever—when stricken with typhus in 1813, he instructed that he be treated through bloodletting and purging—but at his death, a grateful populace turned out en masse to pay tribute to one of Philadelphia’s most honored citizens.

In his 2018 biography, Rush: Revolution, Madness, and Benjamin Rush, the Visionary Doctor Who Became a Founding Father, Stephen Fried explained how the physician-patriot’s intimate connection to the leading lights of his time led to his relative undervaluation by decades of historians. At his death, descendants of several prominent families had reason not to have his correspondence or journal entries cited by biographers--materials that would have confirmed his central in the American Revolution:

*Jefferson’s family did not want airing of his skepticism about the divinity of Christ—opinions that could have been misconstrued to suggest he was an atheist—or his request to the doctor for the best way to treat his hemorrhoids;

*Adams’ descendants were sensitive about revealing the President's anguish over a son’s descent into and death from alcoholism—a pattern that repeated itself with one of the children of John Quincy Adams; and

*Rush’s family was not keen about divulging the reason behind his disrupted friendship with George Washington, now firmly established as the Father of His Country.

Even as he struggled with the personal tragedy of his son John--a physician who, after killing a friend in a duel, became so mentally unstable he needed to be placed under his father's care-- Rush, in his last decade, performed one of his greatest services to posterity by relentlessly urging old friends Adams and Jefferson to repair the breach that had developed because of their competition for the Presidency. 

That reconciliation not only helped heal old wounds between the proud old patriots but led to one of the most extraordinary bursts of correspondents among two ex-Presidents—creating a treasure trove that scholars have used since to better understand the extraordinary generation that produced such revolutionaries as Adams, Jefferson and mutual friend Rush.

Saturday, February 23, 2008

This Day in Medical History (Salk Starts Last Phase of Polio-Vaccine Program)

February 23, 1954 – As part of the third and most important pilot program of his major medical discovery, at Arsenal School in the working-class Pittsburgh neighborhood of Lawrenceville, Dr. Jonas E. Salk (pictured) immunized 137 five-to-nine-year-old schoolchildren with his new polio vaccine. The school was the first to participate in the city-wide experiment that within a month would inoculate 7,000 children.

The vaccine came not a month too soon: the summer of 1952 produced the worst polio epidemic in U.S. history, with 57,628 coming down with the disease. On the same day that Salk tried his vaccine out on the Arsenal students, The New York Times reported on a scientific panel’s conclusion that mass inoculations with gamma globulin of 185,000 children in 23 areas the prior summer had failed to produce demonstrably beneficial results against polio.

Salk developed his vaccine while working at the University of Pittsburgh’s School of Medicine. In his laboratories on the ground floor and in the basement, he used rhesus monkeys. According to Franklin Toker’s Pittsburgh: An Urban Portrait (1986), the walls “were said to bear the paw prints of animals that had scampered out of their cages.” (The building—the former Municipal Hospital—is now named in Salk’s honor.)

On April 12, 1955—ten years to the day after the death of the world’s most famous polio victim,
President Franklin D. Roosevelt—Salk announced the successful conclusion of this medical experiment.

Though not well known nowadays, a major force behind Salk’s pioneering work was
Basil O’Connor, FDR’s law partner. Establishing the National Foundation for Infantile Paralysis at his old partner’s request, O’Connor spearheaded the March of Dimes fundraising campaign that brought in $50 million a year ($250 million in 1995 dollars) by the late 1940s.

Intent on moving beyond supplying iron lungs, O’Connor saw killed-virus vaccines as an alternative to live vaccines, which had given researchers unexpected problems. He persuaded Salk to come to the University of Pittsburgh with the promise of a professorship.

O’Connor may have performed his greatest bit of service for Salk, however, in a case of medical politics. Twice, Salk saw his applications for funding for the killed-virus vaccine rejected by the scientific advisory committee of the National Foundation for Infantile Paralysis. On Salk’s third try, the committee told O’Connor that it would not stand in the way of the doctor’s grant.

By 1960, Salk’s vaccine had all but eliminated polio from the general population.

When O’Connor died in 1972, Salk paid tribute to his old benefactor at a memorial service: “In 80 years, what centuries could not do, he did…He used time well and time did not misuse him. Hence, miracles were wrought. His accomplishments are woven into the fabric of existence. He made history happen.”

Friday, January 11, 2008

This Day in Medical History

Jan. 11, 1922 – A Toronto resident, 14-year-old Leonard Thompson, becomes the first patient to receive injections of insulin, a new medication for treating the dreaded “sugar disease.” Diabetic for the last two and a half years, Thompson had already beaten the automatic death sentence given to most Type 1 diabetes patients of the time. But his situation had become dire, as he had fallen to 65 pounds and was about to slip into a coma.

Fortunately, Thompson was about to benefit from months of work on one of the great medical discoveries of the 20th century. It all began with an overly anxious medical instructor, Dr. Frederick Banting, who, thinking his lecture for his first-year students the next day wasn’t good enough, took his medical journal to bed. Waking in the middle of the night, he wrote down his inspiration – the idea that would lead to insulin.

After laboring through sweltering summer of 1921 in a University of Toronto laboratory, Banting and his assistant, Charles Best, successfully tested a pancreatic extract on a diabetic dog. Banting’s paper on his discovery, delivered six months later at Yale University, received a tepid reception. But after some initial skepticism, he had won the approval of Dr. John J.R. MacLeod of the university’s physiology department, who put at Banting’s disposal as many resources – notably lab space and a team of assistants – to continue his explorations.

Thompson’s first injections of pancreatic extract, prepared by Banting and Best, were followed two weeks later by a purified extract from chemist James Bertram Collip. By the end of February, with Thompson’s blood sugar returning to normal and his strength returning, the procedure is considered a success.

In May 1922, Eli Lilly and Co. and the University of Toronto signed a deal for the mass production of insulin in North America. In 1923, Banting and MacLeod were awarded the Nobel Prize in medicine/physiology (a much-needed boon to the soft-spoken, modest Banting, who had been so broke during his summer in the hot laboratory that his father and brother funded his work). The two Nobel Prize laureates shared their awards with their closest colleagues – Banting with Best, MacLeod with Collip. Twelve years after the successful injection of Thompson, Banting was knighted for his pioneering medical research.

Though he eventually died of diabetes complications, Thompson had managed to live 15 years after the first injection – an astounding advance for the time. Today, it is estimated that more than 15 million diabetics are alive today because of the drug.

As great a success story as this is, the full benefits of insulin have still not reached all corners of the world, even eighty-six years later. An estimated 19,000 Type 1 diabetes patients exist in 41 countries defined by the World Bank and the International Monetary Fund as “Highly Indebted Poor Countries.” That economic deprivation has resulted in life expectancies of as little as one year for children with newly diagnosed Type 1 diabetes in much of sub-Saharan Africa.